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desvenlafaxine will increase the amount or influence of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) lower the CYP2D6 substrate dose by up to fifty%; no dosage adjustment needed with desvenlafaxine doses seven consecutive times instantly p